Jacqueline M. Linehan

33 Cleveland Street, W1W 7FF
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 35 publications

A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions.

A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: June 30, 2026

Strain-specific propagation of variant Creutzfeldt-Jakob disease prions in humanized neural cells.

Strain-specific propagation of variant Creutzfeldt-Jakob disease prions in humanized neural cells.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: June 11, 2026

Correction: Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

Correction: Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

Journal: Acta neuropathologica

Published: March 30, 2026

Modification of early behavioural, physiological and neuropathological endpoints by syntaxin-6 knockout in a humanised P301S transgenic model of tauopathy.

Modification of early behavioural, physiological and neuropathological endpoints by syntaxin-6 knockout in a humanised P301S transgenic model of tauopathy.

Journal: Acta neuropathologica

Published: January 22, 2026

Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

Journal: Acta neuropathologica

Published: August 02, 2025

Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.

Journal: Acta neuropathologica

Published: August 02, 2025

Isolation of a novel human prion strain from a PRNP codon 129 heterozygous vCJD patient.

Isolation of a novel human prion strain from a PRNP codon 129 heterozygous vCJD patient.

Journal: PLoS pathogens

Published: October 22, 2024

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.

Journal: Neurobiology of disease

Published: August 16, 2023

DNA methylation analysis of archival lymphoreticular tissues in Creutzfeldt-Jakob disease.

DNA methylation analysis of archival lymphoreticular tissues in Creutzfeldt-Jakob disease.

Journal: Acta neuropathologica

Published: June 15, 2022

Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme.

Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme.

Journal: The Lancet. Neurology

Published: October 22, 2021

Overexpression of mouse prion protein in transgenic mice causes a non-transmissible spongiform encephalopathy.

Overexpression of mouse prion protein in transgenic mice causes a non-transmissible spongiform encephalopathy.

Journal: Scientific reports

Published: October 19, 2021

Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose.

Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose.

Journal: The Journal of infectious diseases

Published: December 01, 2020

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Last Updated: 09/26/2026