Jakub Chrustowicz

Martinsried, BY, Germany

Last Updated: 09/26/2026

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Found 14 publications

Charged molecular glue discovery enabled by targeted degron display.

Charged molecular glue discovery enabled by targeted degron display.

Journal: Nature chemical biology
Published: December 13, 2025

The many faces of the GID/CTLH E3 ligase complex.

The many faces of the GID/CTLH E3 ligase complex.

Journal: Biochemical Society transactions
Published: March 31, 2025

Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly.

Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly.

Journal: FEBS letters
Published: December 16, 2023

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.

Journal: Molecular cell
Published: September 13, 2023

Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.

Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.

Journal: Molecular cell
Published: July 11, 2023

Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation.

Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation.

Journal: eLife
Published: February 16, 2022

How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini.

How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini.

Journal: Molecular cell
Published: December 15, 2021

Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation.

Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation.

Journal: Nature communications
Published: October 07, 2021

Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases.

Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases.

Journal: Journal of molecular biology
Published: August 31, 2021

A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters.

A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters.

Journal: EMBO reports
Published: August 18, 2021

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.

Journal: Molecular cell
Published: October 15, 2020

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.

Journal: Molecular cell
Published: August 02, 2019
Showing 1-12 of 14

Last Updated: 09/26/2026