James A. Duce

Hills Road
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 52 publications

Modelling Ferroptosis in a Human Microglial Line by Sequential Exposure to Iron and GPX4 Inhibition.

Modelling Ferroptosis in a Human Microglial Line by Sequential Exposure to Iron and GPX4 Inhibition.

Journal: Oxidative medicine and cellular longevity

Published: February 10, 2026

Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.

Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.

Journal: Frontiers in cellular neuroscience

Published: November 03, 2025

Lower levels of soluble β-amyloid precursor protein, but not β-amyloid, in the frontal cortex in schizophrenia.

Lower levels of soluble β-amyloid precursor protein, but not β-amyloid, in the frontal cortex in schizophrenia.

Journal: Psychiatry research

Published: August 18, 2023

Artificial intelligence for dementia drug discovery and trials optimization.

Artificial intelligence for dementia drug discovery and trials optimization.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: February 17, 2023

Trial of Deferiprone in Parkinson's Disease.

Trial of Deferiprone in Parkinson's Disease.

Journal: The New England journal of medicine

Published: November 30, 2022

ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons.

ACSL4 and the lipoxygenases 15/15B are pivotal for ferroptosis induced by iron and PUFA dyshomeostasis in dopaminergic neurons.

Journal: Free radical biology & medicine

Published: November 05, 2022

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition.

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition.

Journal: Cell reports

Published: April 21, 2022

Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease.

Synthesis, physicochemical characterization and neuroprotective evaluation of novel 1-hydroxypyrazin-2(1H)-one iron chelators in an in vitro cell model of Parkinson's disease.

Journal: Dalton transactions (Cambridge, England : 2003)

Published: February 11, 2022

The Key Factors Predicting Dementia in Individuals With Alzheimer's Disease-Type Pathology.

The Key Factors Predicting Dementia in Individuals With Alzheimer's Disease-Type Pathology.

Journal: Frontiers in aging neuroscience

Published: December 09, 2021

Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis.

Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis.

Journal: Biomaterials

Published: May 20, 2021

The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of Aβ burden through induction of APP amyloidogenic processing.

The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of Aβ burden through induction of APP amyloidogenic processing.

Journal: Molecular psychiatry

Published: February 22, 2021

Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get.

Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get.

Journal: Journal of neurochemistry

Published: May 08, 2020

Showing 1-12 of 52

Last Updated: 09/26/2026