James F. Whitfield
1200 Montreal Road
Ottawa, ON K1A0R6, Canada
Ottawa, ON K1A0R6, Canada
Last Updated: 09/26/2026
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Found 18 publications
The blood-brain barrier-penetrating fusion protein BBB-ABP selectively binds amyloid-β oligomers and prevents in vitro neurotoxicity.
Journal: Journal of Alzheimer's disease : JAD
Published: June 30, 2026
Alzheimer's Disease and Its Possible Evolutionary Origin: Hypothesis.
Journal: Cells
Published: April 01, 2023
Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer's Disease in Rat and Dog.
Journal: Pharmaceutical research
Published: March 09, 2022
Targeting Human Astrocytes' Calcium-sensing Receptors for Treatment of Alzheimer's Disease.
Journal: Current pharmaceutical design
Published: May 02, 2017
Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients.
Journal: Neurochemistry international
Published: March 26, 2016
Preventing the spread of Alzheimer's disease neuropathology: a role for calcilytics?
Journal: Current pharmaceutical biotechnology
Published: December 24, 2014
Do astrocytes collaborate with neurons in spreading the "infectious" aβ and Tau drivers of Alzheimer's disease?
Journal: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Published: April 18, 2014
The Aβ peptides-activated calcium-sensing receptor stimulates the production and secretion of vascular endothelial growth factor-A by normoxic adult human cortical astrocytes.
Journal: Neuromolecular medicine
Published: February 13, 2014
Evidence that a synthetic amyloid-ß oligomer-binding peptide (ABP) targets amyloid-ß deposits in transgenic mouse brain and human Alzheimer's disease brain.
Journal: Biochemical and biophysical research communications
Published: February 05, 2014
Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.
Journal: Biochimica et biophysica acta
Published: November 27, 2012
A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds β-amyloid (Aβ1-42 ) oligomers.
Journal: Journal of neurochemistry
Published: September 25, 2012
Last Updated: 09/26/2026