James L. Hutchinson

University Walk
Bristol, ENG BS81TD, United Kingdom

Last Updated: 09/26/2026

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Found 15 publications

A Rac-PI3Kβ feedback loop drives GPVI-dependent platelet activation.

A Rac-PI3Kβ feedback loop drives GPVI-dependent platelet activation.

Journal: iScience
Published: August 11, 2025

Constitutive surface expression of the thromboxane A2 receptor is Pim kinase-dependent.

Constitutive surface expression of the thromboxane A2 receptor is Pim kinase-dependent.

Journal: Journal of thrombosis and haemostasis : JTH
Published: May 15, 2024

Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors.

Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors.

Journal: British journal of pharmacology
Published: October 10, 2023

Ticagrelor inverse agonist activity at the P2Y12 receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate.

Ticagrelor inverse agonist activity at the P2Y12 receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate.

Journal: British journal of pharmacology
Published: June 28, 2022

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.

Journal: International journal of molecular sciences
Published: July 27, 2021

Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial.

Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial.

Journal: Journal of the American Heart Association
Published: December 11, 2020

Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner.

Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner.

Journal: Scientific reports
Published: November 30, 2020

Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling.

Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling.

Journal: Blood advances
Published: August 12, 2020

Arrestin-3 differentially regulates platelet GPCR subsets.

Arrestin-3 differentially regulates platelet GPCR subsets.

Journal: Platelets
Published: November 06, 2019

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling.

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling.

Journal: Haematologica
Published: April 01, 2019

Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation.

Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation.

Journal: Cellular signalling
Published: February 06, 2018

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Journal: Blood advances
Published: December 16, 2017
Showing 1-12 of 15

Last Updated: 09/26/2026