Last Updated: 09/26/2026
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Found 13 publications
Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet.
Journal: The journals of gerontology. Series A, Biological sciences and medical sciences
Published: March 13, 2020
Sirtuin activators and inhibitors: Promises, achievements, and challenges.
Journal: Pharmacology & therapeutics
Published: March 27, 2018
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.
Journal: Cell metabolism
Published: January 31, 2017
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.
Journal: Shock (Augusta, Ga.)
Published: March 15, 2016
Sirtuin 1 activator SRT2104 protects Huntington's disease mice.
Journal: Annals of clinical and translational neurology
Published: June 10, 2014
The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
Journal: European heart journal
Published: March 08, 2014
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Journal: Aging cell
Published: February 24, 2014
Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.
Journal: Cell cycle (Georgetown, Tex.)
Published: July 30, 2013
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet.
Journal: Cell reports
Published: July 18, 2013
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Journal: Science (New York, N.Y.)
Published: March 09, 2013
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: January 24, 2013
Identification of a SIRT1 mutation in a family with type 1 diabetes.
Journal: Cell metabolism
Published: October 18, 2012
Last Updated: 09/26/2026