James M. Staddon

Mosquito Way
Hatfield, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 10 publications

Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.

Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.

Journal: Cell reports methods

Published: July 07, 2025

Advancing novel therapies for neurodegeneration through an innovative model for industry-academia collaborations: A decade of the Eisai-UCL experience.

Advancing novel therapies for neurodegeneration through an innovative model for industry-academia collaborations: A decade of the Eisai-UCL experience.

Journal: Drug discovery today

Published: December 20, 2022

Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones.

Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones.

Journal: Bioorganic & medicinal chemistry letters

Published: November 01, 2022

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.

Journal: SLAS discovery : advancing life sciences R & D

Published: October 20, 2022

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches.

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches.

Journal: The Biochemical journal

Published: July 02, 2021

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.

Journal: Scientific reports

Published: March 18, 2021

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease.

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease.

Journal: Acta neuropathologica communications

Published: December 05, 2019

Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification.

Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification.

Journal: Haematologica

Published: September 28, 2019

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria.

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria.

Journal: Scientific reports

Published: April 26, 2016

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.

Journal: Human molecular genetics

Published: June 28, 2012

Showing 1-10 of 10

Last Updated: 09/26/2026