James N. Samsom

Toronto, ON M5T1R8, Canada

Last Updated: 09/26/2026

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Found 19 publications

Maternal immune activation causes sex-specific impairment of microglial function during prefrontal cortex development.

Maternal immune activation causes sex-specific impairment of microglial function during prefrontal cortex development.

Journal: Brain, behavior, and immunity

Published: December 17, 2025

Single-cell RNA sequencing uncovers molecular features underlying microglial lipid accumulation and depression-related behaviors in high-fat diet mouse model of obesity.

Single-cell RNA sequencing uncovers molecular features underlying microglial lipid accumulation and depression-related behaviors in high-fat diet mouse model of obesity.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Published: July 22, 2025

Anesthetics as emerging therapeutics for post-traumatic stress disorder (PTSD): bridging bench and bedside.

Anesthetics as emerging therapeutics for post-traumatic stress disorder (PTSD): bridging bench and bedside.

Journal: Molecular psychiatry

Published: June 24, 2025

Exposure to "Forever Chemical" perfluorooctanoic acid induces depression-like behaviors in mice by activating the HPA axis.

Exposure to "Forever Chemical" perfluorooctanoic acid induces depression-like behaviors in mice by activating the HPA axis.

Journal: Environment international

Published: April 01, 2025

nNOS-expressing neurons in the mPFC mediate depression-related behaviors in mice through pPVT-mPFC projections.

nNOS-expressing neurons in the mPFC mediate depression-related behaviors in mice through pPVT-mPFC projections.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Published: March 13, 2025

Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice.

Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice.

Journal: Cells

Published: November 04, 2024

Protein interacting with C-kinase 1 (PICK1) regulates synaptic function and reversal learning in a mouse model for schizophrenia.

Protein interacting with C-kinase 1 (PICK1) regulates synaptic function and reversal learning in a mouse model for schizophrenia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Published: October 22, 2024

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction.

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: October 21, 2024

PolyI:C Maternal Immune Activation on E9.5 Causes the Deregulation of Microglia and the Complement System in Mice, Leading to Decreased Synaptic Spine Density.

PolyI:C Maternal Immune Activation on E9.5 Causes the Deregulation of Microglia and the Complement System in Mice, Leading to Decreased Synaptic Spine Density.

Journal: International journal of molecular sciences

Published: April 10, 2024

Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis.

Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis.

Journal: Science advances

Published: December 08, 2023

EF1α-associated protein complexes affect dendritic spine plasticity by regulating microglial phagocytosis in Fmr1 knock-out mice.

EF1α-associated protein complexes affect dendritic spine plasticity by regulating microglial phagocytosis in Fmr1 knock-out mice.

Journal: Molecular psychiatry

Published: May 11, 2023

Excessive left anterior hippocampal and caudate activation in schizophrenia underlie cognitive underperformance in a virtual navigation task.

Excessive left anterior hippocampal and caudate activation in schizophrenia underlie cognitive underperformance in a virtual navigation task.

Journal: Psychiatry research. Neuroimaging

Published: July 04, 2022

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Last Updated: 09/26/2026