James P. O'connell

Pain Medicine
234 E 149th St
Bronx, NY 10451

Last Updated: 09/26/2026

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Found 7 publications

Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.

Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.

Journal: Frontiers in pharmacology
Published: August 12, 2024

Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF.

Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF.

Journal: Bioanalysis
Published: April 07, 2023

An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.

An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.

Journal: Frontiers in pharmacology
Published: September 06, 2022

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.

Journal: Nature communications
Published: May 22, 2020

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.

Journal: Nature communications
Published: April 10, 2019

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF.

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF.

Journal: Nature communications
Published: December 20, 2017

mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging.

mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging.

Journal: BMC cell biology
Published: June 21, 2012
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Last Updated: 09/26/2026