James R. Downing

Pulmonary Medicine
3504 S Lafountain St
Kokomo, IN 46902

Last Updated: 09/26/2026

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Found 121 publications

Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML.

Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML.

Journal: Blood advances
Published: May 02, 2022

Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.

Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.

Journal: Blood cancer discovery
Published: August 27, 2021

The genomic landscape of pediatric acute lymphoblastic leukemia.

The genomic landscape of pediatric acute lymphoblastic leukemia.

Journal: Nature genetics
Published: July 16, 2021

Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.

Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.

Journal: Blood cancer discovery
Published: July 12, 2021

Acute lymphoblastic leukemia displays a distinct highly methylated genome.

Acute lymphoblastic leukemia displays a distinct highly methylated genome.

Journal: Nature cancer
Published: May 18, 2021

Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.

Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.

Journal: Blood cancer discovery
Published: March 17, 2021

A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.

A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.

Journal: Blood advances
Published: March 01, 2021

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing.

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing.

Journal: Cancer discovery
Published: November 24, 2020

DNA Methylation Clusters and Their Relation to Cytogenetic Features in Pediatric AML.

DNA Methylation Clusters and Their Relation to Cytogenetic Features in Pediatric AML.

Journal: Cancers
Published: September 26, 2020

St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem.

St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem.

Journal: Cancer discovery
Published: August 21, 2020

Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).

Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).

Journal: Scientific reports
Published: July 27, 2020

Pathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Treatment Exposures and Risk of Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

Pathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Treatment Exposures and Risk of Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Published: June 05, 2020
Showing 1-12 of 121

Last Updated: 09/26/2026