James R. Edgar

Tennis Court Road
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 48 publications

Gene editing of alveolar organoids reveals AT2 dysfunction due to endosomal SFTPC accumulation.

Gene editing of alveolar organoids reveals AT2 dysfunction due to endosomal SFTPC accumulation.

Journal: American journal of respiratory cell and molecular biology

Published: March 04, 2026

Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif.

Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif.

Journal: mBio

Published: August 18, 2025

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing.

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing.

Journal: bioRxiv : the preprint server for biology

Published: August 08, 2025

Exosome Tethering Requires Tetherin Homodimerisation.

Exosome Tethering Requires Tetherin Homodimerisation.

Journal: Biology of the cell

Published: August 07, 2025

Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation.

Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation.

Journal: Science immunology

Published: July 18, 2025

The EMCV protein 2B* is required for efficient cell lysis via both caspase-3-dependent and -independent pathways during infection.

The EMCV protein 2B* is required for efficient cell lysis via both caspase-3-dependent and -independent pathways during infection.

Journal: The Journal of general virology

Published: February 10, 2025

Tethered Exosomes Containing the Matrix Metalloproteinase MT1-MMP Contribute to Extracellular Matrix Degradation.

Tethered Exosomes Containing the Matrix Metalloproteinase MT1-MMP Contribute to Extracellular Matrix Degradation.

Journal: Journal of extracellular vesicles

Published: November 28, 2024

Human placental cells are resistant to SARS-CoV-2 infection and replication.

Human placental cells are resistant to SARS-CoV-2 infection and replication.

Journal: Wellcome open research

Published: November 04, 2024

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.

Journal: The EMBO journal

Published: September 11, 2024

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

Journal: Frontiers in immunology

Published: January 22, 2024

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.

Journal: bioRxiv : the preprint server for biology

Published: September 11, 2023

Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

Journal: Journal of extracellular vesicles

Published: August 10, 2023

Showing 1-12 of 48

Last Updated: 09/26/2026