Jan Heering

Frankfurt Am Main, HE 60596, Germany

Last Updated: 09/26/2026

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Found 67 publications

First Structure-Activity-Relationship Study of Potent G2A Antagonists.

First Structure-Activity-Relationship Study of Potent G2A Antagonists.

Journal: Journal of medicinal chemistry

Published: June 11, 2026

Structure Merging Approach Leads to New Dual Potent and Selective USP25/USP28 Inhibitors.

Structure Merging Approach Leads to New Dual Potent and Selective USP25/USP28 Inhibitors.

Journal: Journal of medicinal chemistry

Published: April 22, 2026

Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.

Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.

Journal: Journal of medicinal chemistry

Published: June 18, 2025

A First-in-Class Hepatocyte Nuclear Factor 4 Agonist.

A First-in-Class Hepatocyte Nuclear Factor 4 Agonist.

Journal: Journal of medicinal chemistry

Published: May 08, 2025

Optimization and Evaluation of Complementary Degrader Discovery Assays for Application in Screening.

Optimization and Evaluation of Complementary Degrader Discovery Assays for Application in Screening.

Journal: ACS pharmacology & translational science

Published: March 16, 2025

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation.

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation.

Journal: Frontiers in pharmacology

Published: March 10, 2025

Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.

Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.

Journal: Journal of medicinal chemistry

Published: January 13, 2025

Fragment-Based Discovery of Drug-like LRH-1 Agonists.

Fragment-Based Discovery of Drug-like LRH-1 Agonists.

Journal: ACS medicinal chemistry letters

Published: December 18, 2024

Fatty Acid Mimetic Fragments as Liver Receptor Homologue-1 Modulators.

Fatty Acid Mimetic Fragments as Liver Receptor Homologue-1 Modulators.

Journal: ACS pharmacology & translational science

Published: December 17, 2024

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design.

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design.

Journal: Communications chemistry

Published: October 18, 2024

SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.

SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: October 04, 2024

Tuning RXR Modulators for PGC1α Recruitment.

Tuning RXR Modulators for PGC1α Recruitment.

Journal: Journal of medicinal chemistry

Published: September 11, 2024

Showing 1-12 of 67

Last Updated: 09/26/2026