Jan Konvalinka

Prague, PR 16610, Czech Republic

Last Updated: 09/26/2026

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Found 78 publications

Making Prodrugs Stick Around: Engineering Protease-Activated Tumor Retention.

Making Prodrugs Stick Around: Engineering Protease-Activated Tumor Retention.

Journal: ACS central science

Published: June 25, 2026

CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive Macrophages.

CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive Macrophages.

Journal: Molecular pharmaceutics

Published: April 21, 2026

Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures.

Prebiotically Plausible Peptides can Self-assemble into β-rich Nanostructures.

Journal: bioRxiv : the preprint server for biology

Published: November 26, 2025

Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights.

Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights.

Journal: ACS infectious diseases

Published: October 30, 2025

Potent Competitive Inhibitors of Ecto-5'-nucleotidase (CD73) based on 6‑(Het)aryl-7-deazapurine Ribonucleoside 5'‑O‑Bisphosphonates.

Potent Competitive Inhibitors of Ecto-5'-nucleotidase (CD73) based on 6‑(Het)aryl-7-deazapurine Ribonucleoside 5'‑O‑Bisphosphonates.

Journal: ACS pharmacology & translational science

Published: October 24, 2025

Uncovering the glutamate carboxypeptidase II microenvironment using a multi-labeling proteomic approach.

Uncovering the glutamate carboxypeptidase II microenvironment using a multi-labeling proteomic approach.

Journal: Scientific reports

Published: August 28, 2025

3'-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex.

3'-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex.

Journal: ChemMedChem

Published: July 03, 2025

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents.

Journal: Journal of medicinal chemistry

Published: April 22, 2025

Identification of 6‑Aryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5'-Nucleotidase (CD73).

Identification of 6‑Aryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5'-Nucleotidase (CD73).

Journal: ACS pharmacology & translational science

Published: March 11, 2025

Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors.

Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors.

Journal: RSC medicinal chemistry

Published: January 22, 2025

The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase.

The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: October 27, 2024

Design, synthesis, and activity evaluation of C-8 arylated luteolin derivatives as influenza endonuclease inhibitors.

Design, synthesis, and activity evaluation of C-8 arylated luteolin derivatives as influenza endonuclease inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: September 17, 2024

Showing 1-12 of 78

Last Updated: 09/26/2026