Jan Snoeys

Janssen R&D
Beerse, VLG, Belgium

Last Updated: 09/26/2026

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Found 87 publications

Metabolism and excretion pathways of CD388, a novel drug-fragment crystallizable conjugate for prevention of seasonal or pandemic influenza.

Metabolism and excretion pathways of CD388, a novel drug-fragment crystallizable conjugate for prevention of seasonal or pandemic influenza.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: December 11, 2025

Deconvoluting the in vitro to in vivo drug clearance gap: Questioning the predictive performance of traditional hepatic clearance models.

Deconvoluting the in vitro to in vivo drug clearance gap: Questioning the predictive performance of traditional hepatic clearance models.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: November 27, 2025

Harnessing human colonoid-derived monolayers as an in vitro platform for investigating accumulation, toxicity, and pharmacodynamics of small molecules.

Harnessing human colonoid-derived monolayers as an in vitro platform for investigating accumulation, toxicity, and pharmacodynamics of small molecules.

Journal: Toxicology in vitro : an international journal published in association with BIBRA

Published: November 12, 2025

Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi.

Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi.

Journal: Chemical research in toxicology

Published: May 06, 2025

Network modeling of sporadic colorectal cancer reveals the importance of off-target effects of Cyclooxygenase inhibitors.

Network modeling of sporadic colorectal cancer reveals the importance of off-target effects of Cyclooxygenase inhibitors.

Journal: NPJ systems biology and applications

Published: April 10, 2025

Absorption, distribution, metabolism, and excretion of an antiviral drug-Fc conjugate CD388 following subcutaneous administration of 14C-CD388 in the rat.

Absorption, distribution, metabolism, and excretion of an antiviral drug-Fc conjugate CD388 following subcutaneous administration of 14C-CD388 in the rat.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: February 20, 2025

CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes.

CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes.

Journal: Chemical research in toxicology

Published: December 11, 2024

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition.

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: December 06, 2024

Toward improved clearance predictions and distribution profiles employing the isolated perfused rat liver model: Experimental optimization.

Toward improved clearance predictions and distribution profiles employing the isolated perfused rat liver model: Experimental optimization.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: November 25, 2024

Selective HLA Class II Allele-Restricted Activation of Atabecestat Metabolite-Specific Human T-Cells.

Selective HLA Class II Allele-Restricted Activation of Atabecestat Metabolite-Specific Human T-Cells.

Journal: Chemical research in toxicology

Published: September 30, 2024

Therapeutic siRNA Loaded to RISC as Single and Double Strands Requires an Appropriate Quantitative Assay for RISC PK Assessment.

Therapeutic siRNA Loaded to RISC as Single and Double Strands Requires an Appropriate Quantitative Assay for RISC PK Assessment.

Journal: Nucleic acid therapeutics

Published: April 19, 2024

Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel bioavailability in rats.

Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel bioavailability in rats.

Journal: International journal of pharmaceutics

Published: January 22, 2024

Showing 1-12 of 87

Last Updated: 09/26/2026