Janette Mezeyova

Burnaby, BC V5G4W8, Canada

Last Updated: 09/26/2026

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Found 10 publications

Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.

Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.

Journal: ACS chemical neuroscience

Published: February 15, 2024

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

Journal: British journal of pharmacology

Published: December 21, 2023

Expanding the genotype-phenotype spectrum in SCN8A-related disorders.

Expanding the genotype-phenotype spectrum in SCN8A-related disorders.

Journal: Research square

Published: August 23, 2023

Expanding the genotype-phenotype spectrum in SCN8A-related disorders.

Expanding the genotype-phenotype spectrum in SCN8A-related disorders.

Journal: BMC neurology

Published: July 31, 2023

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures.

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures.

Journal: Frontiers in cellular neuroscience

Published: June 09, 2022

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

Journal: eLife

Published: July 24, 2021

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Journal: Bioorganic & medicinal chemistry letters

Published: April 07, 2021

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Journal: Journal of medicinal chemistry

Published: March 08, 2021

Inhibitory effects of cannabidiol on voltage-dependent sodium currents.

Inhibitory effects of cannabidiol on voltage-dependent sodium currents.

Journal: The Journal of biological chemistry

Published: July 17, 2018

T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.

T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.

Journal: Science translational medicine

Published: February 21, 2012

Showing 1-10 of 10

Last Updated: 09/26/2026