Jason F. Moffat

160 College Street
Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 178 publications

uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target.

uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target.

Journal: Science translational medicine
Published: May 13, 2026

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.

Journal: bioRxiv : the preprint server for biology
Published: January 16, 2026

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Journal: STAR protocols
Published: January 08, 2026

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Journal: Cell
Published: November 25, 2025

Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma.

Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma.

Journal: International journal of cancer
Published: August 05, 2025

A global genetic interaction map of a human cell reveals conserved principles of genetic networks.

A global genetic interaction map of a human cell reveals conserved principles of genetic networks.

Journal: bioRxiv : the preprint server for biology
Published: July 09, 2025

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis.

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis.

Journal: Science translational medicine
Published: July 02, 2025

CRISPR-Cas9-Guided Genetic Manipulation of Patient-Derived Brain Tumor Cells.

CRISPR-Cas9-Guided Genetic Manipulation of Patient-Derived Brain Tumor Cells.

Journal: Methods in molecular biology (Clifton, N.J.)
Published: June 24, 2025

A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns.

A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns.

Journal: Cell reports
Published: June 23, 2025

CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma.

CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma.

Journal: Scientific reports
Published: May 29, 2025

Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways.

Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways.

Journal: Nature communications
Published: March 18, 2025

A clinical drug candidate that triggers non-apoptotic cancer cell death.

A clinical drug candidate that triggers non-apoptotic cancer cell death.

Journal: Research square
Published: February 24, 2025
Showing 1-12 of 178

Last Updated: 09/26/2026