Jason M. O'brien

Science And Technology Branch
Ottawa, ON, Canada

Last Updated: 09/26/2026

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Found 66 publications

Methods2AOP: A Collaboration to Strengthen the Integration of Test Methods into the Adverse Outcome Pathway Framework.

Methods2AOP: A Collaboration to Strengthen the Integration of Test Methods into the Adverse Outcome Pathway Framework.

Journal: F1000Research

Published: January 30, 2026

In vitro screening of 13 diverse organic flame retardants reveals that phosphorous-based compounds elicit greater effects on cell viability and gene expression in chicken hepatic cells.

In vitro screening of 13 diverse organic flame retardants reveals that phosphorous-based compounds elicit greater effects on cell viability and gene expression in chicken hepatic cells.

Journal: Environmental toxicology and chemistry

Published: January 29, 2026

In vitro screening of 13 diverse organic flame retardants reveals that phosphorous-based compounds elicit greater effects on cell viability and gene expression in chicken hepatic cells.

In vitro screening of 13 diverse organic flame retardants reveals that phosphorous-based compounds elicit greater effects on cell viability and gene expression in chicken hepatic cells.

Journal: Environmental toxicology and chemistry

Published: January 29, 2026

Avian-Specific Evidence for an Estrogen Receptor Agonism Adverse Outcome Pathway Based on Chicken Embryos and LMH 3D Spheroids Exposed to Ethinylestradiol and Bisphenol A.

Avian-Specific Evidence for an Estrogen Receptor Agonism Adverse Outcome Pathway Based on Chicken Embryos and LMH 3D Spheroids Exposed to Ethinylestradiol and Bisphenol A.

Journal: Environmental science & technology

Published: May 19, 2025

Acute toxicity, behaviour, metabolism, and transcriptomic points of departure in embryo-larval zebrafish exposed to nine different PFAS.

Acute toxicity, behaviour, metabolism, and transcriptomic points of departure in embryo-larval zebrafish exposed to nine different PFAS.

Journal: Journal of hazardous materials

Published: April 22, 2025

Adverse Outcome Pathway (AOP) Coaching Program-how it functions and contributes to a more harmonized approach to AOP development and construction of AOP networks with regulatory utility.

Adverse Outcome Pathway (AOP) Coaching Program-how it functions and contributes to a more harmonized approach to AOP development and construction of AOP networks with regulatory utility.

Journal: Environmental toxicology and chemistry

Published: February 17, 2025

Association of Hepatic Gene Expression with Chemical Concentrations in Wild-Collected Double-Crested Cormorant Embryos using an EcoToxChip Gene Array.

Association of Hepatic Gene Expression with Chemical Concentrations in Wild-Collected Double-Crested Cormorant Embryos using an EcoToxChip Gene Array.

Journal: Environmental science & technology

Published: December 24, 2024

Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities.

Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: November 05, 2024

Comparison of gene expression and polycyclic aromatic compound profiles in hepatic tissue of black guillemot (Cepphus grylle) collected from an oil spill site and a non-spill site in the Arctic.

Comparison of gene expression and polycyclic aromatic compound profiles in hepatic tissue of black guillemot (Cepphus grylle) collected from an oil spill site and a non-spill site in the Arctic.

Journal: Marine pollution bulletin

Published: October 29, 2024

Gene Set Enrichment Analysis in Zebrafish Embryos Is Susceptible to False-Positive Results in the Absence of Differentially Expressed Genes.

Gene Set Enrichment Analysis in Zebrafish Embryos Is Susceptible to False-Positive Results in the Absence of Differentially Expressed Genes.

Journal: Bioinformatics and biology insights

Published: October 15, 2024

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening.

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening.

Journal: Frontiers in toxicology

Published: August 18, 2024

Empirical Characterization of False Discovery Rates of Differentially Expressed Genes and Transcriptomic Benchmark Concentrations in Zebrafish Embryos.

Empirical Characterization of False Discovery Rates of Differentially Expressed Genes and Transcriptomic Benchmark Concentrations in Zebrafish Embryos.

Journal: Environmental science & technology

Published: March 26, 2024

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Last Updated: 09/26/2026