Last Updated: 09/26/2026
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Found 27 publications
Discovery of CNS Penetrant SOS1 Inhibitors for the Treatment of KRAS-Dependent Cancers.
Journal: Journal of medicinal chemistry
Published: June 16, 2026
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen.
Journal: ACS medicinal chemistry letters
Published: June 07, 2025
Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1.
Journal: ACS medicinal chemistry letters
Published: May 16, 2025
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: September 05, 2023
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
Journal: Journal of medicinal chemistry
Published: July 03, 2023
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
Journal: Journal of medicinal chemistry
Published: February 02, 2023
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.
Journal: Journal of medicinal chemistry
Published: April 26, 2022
Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
Journal: Journal of medicinal chemistry
Published: September 10, 2020
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C.
Journal: Journal of medicinal chemistry
Published: February 06, 2020
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC).
Journal: Journal of medicinal chemistry
Published: November 12, 2019
Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.
Journal: ACS medicinal chemistry letters
Published: August 08, 2019
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Journal: Nature communications
Published: October 16, 2018
Last Updated: 09/26/2026