Jean-marie B. Nicolas
Braine L'alleud, Belgium
Last Updated: 09/26/2026
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Found 30 publications
Breaking the 1% unbound threshold: an IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: January 28, 2026
Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.
Journal: Frontiers in pharmacology
Published: August 12, 2024
Contribution of the Dynamic Intestinal Absorption Model (Diamod) to the Development of a Patient-Centric Drug Formulation.
Journal: Molecular pharmaceutics
Published: November 13, 2023
A New Version of the Tissue Composition-Based Model for Improving the Mechanism-Based Prediction of Volume of Distribution at Steady-State for Neutral Drugs.
Journal: Journal of pharmaceutical sciences
Published: July 05, 2023
Pharmacokinetics, Safety, and Tolerability of Brivaracetam in Healthy Elderly Participants.
Journal: Clinical pharmacology in drug development
Published: February 20, 2023
Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A.
Journal: EJNMMI research
Published: August 10, 2022
Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines.
Journal: Advanced drug delivery reviews
Published: September 11, 2021
Use of a physiologically based pharmacokinetic-pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial.
Journal: British journal of clinical pharmacology
Published: April 17, 2020
Impact of In Vitro Passive Permeability in a P-gp-transfected LLC-PK1 Model on the Prediction of the Rat and Human Unbound Brain-to-Plasma Concentration Ratio.
Journal: Pharmaceutical research
Published: March 27, 2020
A review of the drug-drug interactions of the antiepileptic drug brivaracetam.
Journal: Epilepsy research
Published: January 15, 2020
Assessment of a white matter reference region for 11C-UCB-J PET quantification.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published: October 02, 2019
Last Updated: 09/26/2026