Jean-michel Flaman

Lyon, France

Last Updated: 09/26/2026

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Found 29 publications

The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A-Dependent Upregulation and a FURIN-Dependent Cleavage of the ANGPTL4 Secreted Factor.

The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A-Dependent Upregulation and a FURIN-Dependent Cleavage of the ANGPTL4 Secreted Factor.

Journal: Aging cell
Published: January 22, 2025

Regulation of cell function and identity by cellular senescence.

Regulation of cell function and identity by cellular senescence.

Journal: The Journal of cell biology
Published: March 21, 2024

A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression.

A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression.

Journal: Redox biology
Published: February 23, 2024

RSK3 switches cell fate: from stress-induced senescence to malignant progression.

RSK3 switches cell fate: from stress-induced senescence to malignant progression.

Journal: Journal of experimental & clinical cancer research : CR
Published: June 22, 2023

Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema.

Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema.

Journal: Aging
Published: April 25, 2023

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.

Journal: Circulation
Published: December 14, 2022

Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets.

Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets.

Journal: Aging cell
Published: August 02, 2022

Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca2+ Levels in Senescent Cells.

Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca2+ Levels in Senescent Cells.

Journal: International journal of molecular sciences
Published: July 01, 2022

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells.

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells.

Journal: Cancer letters
Published: May 30, 2022

Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease.

Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease.

Journal: American journal of respiratory cell and molecular biology
Published: October 14, 2021

NF-κB-dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells.

NF-κB-dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells.

Journal: Aging cell
Published: July 21, 2021

PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.

PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging.

Journal: Cell death & disease
Published: March 24, 2020
Showing 1-12 of 29

Last Updated: 09/26/2026