Jean-pierre Boissel

Lyon, 69000, France

Last Updated: 09/26/2026

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Found 21 publications

Prediction of inclisiran efficacy in patients with established atherosclerotic cardiovascular disease: the SIRIUS in-silico modelling of cardiovascular outcomes.

Prediction of inclisiran efficacy in patients with established atherosclerotic cardiovascular disease: the SIRIUS in-silico modelling of cardiovascular outcomes.

Journal: European journal of preventive cardiology

Published: September 03, 2025

The dawn of in silico clinical trials in cardiovascular diseases: Lessons from the SIRIUS programme.

The dawn of in silico clinical trials in cardiovascular diseases: Lessons from the SIRIUS programme.

Journal: Archives of cardiovascular diseases

Published: June 06, 2025

Credibility assessment of a mechanistic model of atherosclerosis to predict cardiovascular outcomes under lipid-lowering therapy.

Credibility assessment of a mechanistic model of atherosclerosis to predict cardiovascular outcomes under lipid-lowering therapy.

Journal: NPJ digital medicine

Published: September 04, 2024

In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.

In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.

Journal: European journal of preventive cardiology

Published: May 01, 2024

Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance.

Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance.

Journal: Scientific reports

Published: February 05, 2024

In Silico Clinical Trials: Is It Possible?

In Silico Clinical Trials: Is It Possible?

Journal: Methods in molecular biology (Clifton, N.J.)

Published: September 13, 2023

Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma.

Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma.

Journal: BMC bioinformatics

Published: December 15, 2022

Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Solving the Evidence Interpretability Crisis in Health Technology Assessment: A Role for Mechanistic Models?

Journal: Frontiers in medical technology

Published: November 06, 2021

Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions.

Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions.

Journal: Nature communications

Published: October 29, 2021

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.

Journal: CPT: pharmacometrics & systems pharmacology

Published: February 08, 2021

Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample.

Using numerical modeling and simulation to assess the ethical burden in clinical trials and how it relates to the proportion of responders in a trial sample.

Journal: PloS one

Published: January 14, 2021

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.

Journal: CPT: pharmacometrics & systems pharmacology

Published: January 03, 2020

Showing 1-12 of 21

Last Updated: 09/26/2026