Jeff L. Lam

Lensfield Road
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 22 publications

Breaking the glial loop: astrocytic PAD2 and citrullinated vimentin drive microglial dysfunction in Alzheimer's disease.

Breaking the glial loop: astrocytic PAD2 and citrullinated vimentin drive microglial dysfunction in Alzheimer's disease.

Journal: Molecular neurodegeneration

Published: May 28, 2026

Cerebrospinal fluid proteomic signatures reveal APOE genotype-dependent lipid and immune profiles in cognitively unimpaired elderly.

Cerebrospinal fluid proteomic signatures reveal APOE genotype-dependent lipid and immune profiles in cognitively unimpaired elderly.

Journal: Research square

Published: February 12, 2026

Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies.

Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies.

Journal: Cell reports

Published: November 27, 2025

Flipping APOE to reverse Alzheimer's disease traits.

Flipping APOE to reverse Alzheimer's disease traits.

Journal: Nature neuroscience

Published: November 11, 2025

Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.

Single-molecule detection methods to study alpha-synuclein aggregation in postmortem Parkinson's disease brains.

Journal: Cell reports methods

Published: July 07, 2025

A p16 pathway to prevention: Senescence as a driver of tau-mediated neurodegeneration.

A p16 pathway to prevention: Senescence as a driver of tau-mediated neurodegeneration.

Journal: Neuron

Published: June 27, 2025

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: January 23, 2025

Detecting alpha-synuclein aggregates with small molecules on single-molecule array.

Detecting alpha-synuclein aggregates with small molecules on single-molecule array.

Journal: Chemical science

Published: November 11, 2024

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy.

Journal: Cell chemical biology

Published: September 11, 2024

Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.

Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.

Journal: Brain communications

Published: July 06, 2024

Detection of p53 aggregates in plasma of glioma patients.

Detection of p53 aggregates in plasma of glioma patients.

Journal: Communications medicine

Published: May 31, 2024

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.

Journal: Nature communications

Published: February 28, 2024

Showing 1-12 of 22

Last Updated: 09/26/2026