Jelena Melesina

Halle, NI 06120, Germany

Last Updated: 09/26/2026

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Found 33 publications

Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2.

Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD+-Dependent Lysine Deacylase Sirtuin 2.

Journal: Journal of medicinal chemistry

Published: June 07, 2024

Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds.

Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: May 15, 2023

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors.

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors.

Journal: Bioorganic chemistry

Published: September 14, 2022

Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives.

Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives.

Journal: Biochemistry

Published: August 16, 2022

Current trends in development of HDAC-based chemotherapeutics.

Current trends in development of HDAC-based chemotherapeutics.

Journal: Life sciences

Published: July 13, 2022

Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase.

Defined stereoisomers of 2″-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase.

Journal: Bioorganic & medicinal chemistry

Published: March 31, 2022

Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors.

Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors.

Journal: Molecules (Basel, Switzerland)

Published: March 10, 2022

Synthesis, biological evaluation, and molecular docking studies of deoxygenated C-glycosides as LpxC inhibitors.

Synthesis, biological evaluation, and molecular docking studies of deoxygenated C-glycosides as LpxC inhibitors.

Journal: Bioorganic chemistry

Published: August 18, 2021

Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher.

Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher.

Journal: Bioorganic chemistry

Published: July 20, 2021

Strategies To Design Selective Histone Deacetylase Inhibitors.

Strategies To Design Selective Histone Deacetylase Inhibitors.

Journal: ChemMedChem

Published: November 30, 2020

Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors.

Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: March 20, 2020

Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.

Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.

Journal: ChemMedChem

Published: October 18, 2019

Showing 1-12 of 33

Last Updated: 09/26/2026