Jennifer I. Brown

2405 Wesbrook Mall
Vancouver, BC, Canada

Last Updated: 09/26/2026

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Found 12 publications

Challenging the "Undruggable"─Targeting STAT3 but Identifying Potent TrkA-Targeted Inhibitors.

Challenging the "Undruggable"─Targeting STAT3 but Identifying Potent TrkA-Targeted Inhibitors.

Journal: Journal of medicinal chemistry

Published: April 17, 2025

Thermal shift assays in drug discovery - Troubleshooting from biochemical to cellular applications.

Thermal shift assays in drug discovery - Troubleshooting from biochemical to cellular applications.

Journal: Journal of pharmacological and toxicological methods

Published: April 02, 2025

Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens.

Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens.

Journal: European journal of medicinal chemistry

Published: August 23, 2023

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.

Journal: Metabolites

Published: December 15, 2022

The mechanism of Hepatocyte-Targeting and safety profile of Phospholipid-Free small unilamellar vesicles.

The mechanism of Hepatocyte-Targeting and safety profile of Phospholipid-Free small unilamellar vesicles.

Journal: International journal of pharmaceutics

Published: July 20, 2022

Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis.

Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis.

Journal: Amino acids

Published: May 16, 2022

Chemically engineering the drug release rate of a PEG-paclitaxel conjugate using click and steric hindrance chemistries for optimal efficacy.

Chemically engineering the drug release rate of a PEG-paclitaxel conjugate using click and steric hindrance chemistries for optimal efficacy.

Journal: Biomaterials

Published: December 15, 2021

The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.

The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.

Journal: The Journal of biological chemistry

Published: December 06, 2021

Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.

Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.

Journal: Journal of neurochemistry

Published: April 02, 2021

The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.

The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.

Journal: Methods (San Diego, Calif.)

Published: September 03, 2019

Evaluation of kinetic data: What the numbers tell us about PRMTs.

Evaluation of kinetic data: What the numbers tell us about PRMTs.

Journal: Biochimica et biophysica acta. Proteins and proteomics

Published: August 25, 2018

Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism.

Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism.

Journal: Chembiochem : a European journal of chemical biology

Published: September 28, 2017

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Last Updated: 09/26/2026