Jer-cherng Chang

Singapore, 117549, Singapore

Last Updated: 09/26/2026

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Found 10 publications

FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons.

FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons.

Journal: iScience

Published: August 28, 2023

Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?

Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?

Journal: The FEBS journal

Published: July 09, 2021

Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.

Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: October 31, 2020

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

Journal: The Journal of cell biology

Published: October 31, 2019

FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits.

FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits.

Journal: Human molecular genetics

Published: June 05, 2019

The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.

The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.

Journal: Autophagy

Published: January 24, 2019

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.

Journal: eLife

Published: August 05, 2018

Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.

Drosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.

Journal: PloS one

Published: April 06, 2017

Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.

Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.

Journal: Brain research

Published: August 25, 2013

Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila.

Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila.

Journal: G3 (Bethesda, Md.)

Published: April 10, 2012

Showing 1-10 of 10

Last Updated: 09/26/2026