Jiajun M. Yap

8 College Road
Singapore, 169857, Singapore

Last Updated: 09/26/2026

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Found 10 publications

Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold.

Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffold.

Journal: Theranostics

Published: September 20, 2024

BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes.

BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes.

Journal: Molecular cancer

Published: March 14, 2023

Drug resistance in targeted cancer therapies with RAF inhibitors.

Drug resistance in targeted cancer therapies with RAF inhibitors.

Journal: Cancer drug resistance (Alhambra, Calif.)

Published: April 29, 2021

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop.

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop.

Journal: Science advances

Published: December 08, 2020

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.

Journal: Journal of hematology & oncology

Published: June 03, 2020

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods.

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods.

Journal: Journal of visualized experiments : JoVE

Published: August 06, 2019

Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis.

Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis.

Journal: Science signaling

Published: November 01, 2018

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.

Journal: The Journal of biological chemistry

Published: June 26, 2018

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.

Journal: Oncogene

Published: November 23, 2017

Repurposing Zidovudine in combination with Tigecycline for treating carbapenem-resistant Enterobacteriaceae infections.

Repurposing Zidovudine in combination with Tigecycline for treating carbapenem-resistant Enterobacteriaceae infections.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Published: August 22, 2017

Showing 1-10 of 10

Last Updated: 09/26/2026