Last Updated: 09/26/2026
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Found 17 publications
Orally Bioavailable SARS-CoV-2 Protease Inhibitors Bearing a Hydroxymethyl Ketone Warhead.
Journal: Viruses
Published: May 21, 2026
Correction to "Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead".
Journal: Journal of medicinal chemistry
Published: June 14, 2024
Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead.
Journal: Journal of medicinal chemistry
Published: February 09, 2024
Pharmacological YAP activation promotes regenerative repair of cutaneous wounds.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: July 03, 2023
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Journal: Journal of medicinal chemistry
Published: March 14, 2022
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
Journal: Journal of medicinal chemistry
Published: December 11, 2019
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.
Journal: Frontiers in pharmacology
Published: November 23, 2018
Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.
Journal: Journal of medicinal chemistry
Published: August 28, 2018
Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
Journal: ACS medicinal chemistry letters
Published: May 08, 2015
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry letters
Published: November 12, 2014
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.
Journal: ACS medicinal chemistry letters
Published: November 06, 2014
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Journal: Bioorganic & medicinal chemistry letters
Published: August 09, 2013
Last Updated: 09/26/2026