Jian-wen Chen
Guangzhou, China
Last Updated: 09/26/2026
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Found 13 publications
Endothelial PARP1 orchestrates endothelial-to-mesenchymal transition via the PARylation of FHL2 in ischaemic heart failure.
Journal: Acta pharmacologica Sinica
Published: December 09, 2025
ZTW-41, a Potent Indolizinoquinoline-5,12-Dione Derivative Against Drug-Resistant Staphylococci and Enterococci Bacteria.
Journal: Microbial drug resistance (Larchmont, N.Y.)
Published: August 24, 2019
Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
Journal: European journal of medicinal chemistry
Published: March 29, 2019
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.
Journal: Journal of medicinal chemistry
Published: March 28, 2019
Effects of Rich-Polyphenols Extract of Dendrobium loddigesii on Anti-Diabetic, Anti-Inflammatory, Anti-Oxidant, and Gut Microbiota Modulation in db/db Mice.
Journal: Molecules (Basel, Switzerland)
Published: November 11, 2018
Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors.
Journal: European journal of medicinal chemistry
Published: March 28, 2018
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
Journal: Acta pharmacologica Sinica
Published: August 09, 2017
Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives.
Journal: European journal of medicinal chemistry
Published: November 23, 2016
Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway.
Journal: Acta pharmacologica Sinica
Published: September 29, 2016
NADPH oxidase inhibitor regulates microRNAs with improved outcome after mechanical reperfusion.
Journal: Journal of neurointerventional surgery
Published: April 13, 2016
NADPH oxidase inhibitor improves outcome of mechanical reperfusion by suppressing hemorrhagic transformation.
Journal: Journal of neurointerventional surgery
Published: March 04, 2016
ClC-3 deficiency protects preadipocytes against apoptosis induced by palmitate in vitro and in type 2 diabetes mice.
Journal: Apoptosis : an international journal on programmed cell death
Published: September 15, 2014
Last Updated: 09/26/2026