Jiancun Zhang

State Key Laboratory Of Respiratory Disease
Guangzhou, 510530, China

Last Updated: 09/26/2026

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Found 18 publications

Design, synthesis, and biological evaluation of novel 6-aminoalkyl- and 7-heteroaryl substituted 7-deazapurine nucleoside analogs against SARS-CoV-2 replication.

Design, synthesis, and biological evaluation of novel 6-aminoalkyl- and 7-heteroaryl substituted 7-deazapurine nucleoside analogs against SARS-CoV-2 replication.

Journal: Antiviral research

Published: May 22, 2025

Long-Lasting Protection and Dose Optimization of MPXV Polyvalent Mpox mRNA Vaccines Against Lethal Vaccinia Virus Challenge in Mice.

Long-Lasting Protection and Dose Optimization of MPXV Polyvalent Mpox mRNA Vaccines Against Lethal Vaccinia Virus Challenge in Mice.

Journal: Journal of medical virology

Published: October 05, 2024

Design, synthesis, and biological evaluation of novel 2'-deoxy-2'-spirooxetane-7-deazapurine nucleoside analogs as anti-SARS-CoV-2 agents.

Design, synthesis, and biological evaluation of novel 2'-deoxy-2'-spirooxetane-7-deazapurine nucleoside analogs as anti-SARS-CoV-2 agents.

Journal: Antiviral research

Published: September 30, 2024

An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.

An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.

Journal: Nature communications

Published: February 21, 2024

Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus.

Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus.

Journal: Cell reports

Published: November 22, 2023

Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications.

Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications.

Journal: Bioorganic chemistry

Published: August 21, 2023

Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents.

Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents.

Journal: European journal of medicinal chemistry

Published: January 13, 2022

Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification.

Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification.

Journal: Bioorganic chemistry

Published: February 12, 2020

CXCL13/CXCR5 signaling axis in cancer.

CXCL13/CXCR5 signaling axis in cancer.

Journal: Life sciences

Published: March 13, 2019

Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors.

Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors.

Journal: Bioorganic chemistry

Published: November 30, 2018

Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding.

Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding.

Journal: The Journal of biological chemistry

Published: June 28, 2018

Design, synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents.

Design, synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents.

Journal: Antiviral research

Published: April 24, 2017

Showing 1-12 of 18

Last Updated: 09/26/2026