Jiangnan Zhang

Cancer Center And State Key Laboratory Of Biotherapy
Chengdu, China

Last Updated: 09/26/2026

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Found 13 publications

Recent advances in the design of small molecules targeting human ClpP.

Recent advances in the design of small molecules targeting human ClpP.

Journal: Future medicinal chemistry

Published: September 08, 2025

Discovery of potent ClpX modulators with pronounced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

Discovery of potent ClpX modulators with pronounced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).

Journal: European journal of medicinal chemistry

Published: August 19, 2025

Peptide-based rigid nanorod-reinforced gelatin methacryloyl hydrogels for osteochondral regeneration and additive manufacturing.

Peptide-based rigid nanorod-reinforced gelatin methacryloyl hydrogels for osteochondral regeneration and additive manufacturing.

Journal: Nature communications

Published: March 29, 2025

Discovery of 5-(Piperidin-4-yl)-1,2,4-oxadiazole Derivatives as a New Class of Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma.

Discovery of 5-(Piperidin-4-yl)-1,2,4-oxadiazole Derivatives as a New Class of Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma.

Journal: Journal of medicinal chemistry

Published: June 21, 2024

Integrating computational and experimental approaches in discovery and validation of MmpL3 pore domain inhibitors for specific labelling of Mycobacterium tuberculosis.

Integrating computational and experimental approaches in discovery and validation of MmpL3 pore domain inhibitors for specific labelling of Mycobacterium tuberculosis.

Journal: International journal of biological macromolecules

Published: June 17, 2024

Discovery and Optimization of Novel SaFabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.

Discovery and Optimization of Novel SaFabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.

Journal: Journal of medicinal chemistry

Published: June 07, 2024

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment.

Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment.

Journal: Cell reports. Medicine

Published: April 23, 2024

Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.

Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.

Journal: Journal of medicinal chemistry

Published: April 15, 2024

Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response.

Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response.

Journal: Journal of medicinal chemistry

Published: February 08, 2024

Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level.

Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level.

Journal: European journal of medicinal chemistry

Published: January 10, 2024

Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo.

Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo.

Journal: Journal of medicinal chemistry

Published: May 24, 2022

IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro.

IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro.

Journal: Biochemical pharmacology

Published: May 08, 2022

Showing 1-12 of 13

Last Updated: 09/26/2026