Jianhong Yang
Cancer Center And State Key Laboratory Of Biotherapy
Chengdu, 610041, China
Chengdu, 610041, China
Last Updated: 09/26/2026
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Found 58 publications
Identification and Optimization of Pyridone Derivatives as Pan-MEK/RAF Nondegrading Molecular Glues for the Treatment of RAS-Driven Cancers.
Journal: Journal of medicinal chemistry
Published: May 07, 2026
Structure-based design and synthesis of KX-01 analogs as potent antitumor agents targeting the tubulin colchicine binding site.
Journal: European journal of medicinal chemistry
Published: February 06, 2026
Structure-based design and synthesis of 3-substituted-1,2,4-triazolo[1,5-a]pyrimidines as dual vinca/gatorbulin-site ligands for cancer treatment.
Journal: European journal of medicinal chemistry
Published: August 27, 2025
Correction: TAK1 inhibition by natural cyclopeptide RA-V promotes apoptosis and inhibits protective autophagy in Kras-dependent non-small-cell lung carcinoma cells.
Journal: RSC advances
Published: July 07, 2025
Structure of quercetin 3,4'-dimethyl ether in complex with tubulin provides a rationale for drug design.
Journal: Biochemical and biophysical research communications
Published: June 11, 2025
Identification of a ligand-binding site on tubulin mediating the tubulin-RB3 interaction.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: March 11, 2025
Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance.
Journal: Journal of medicinal chemistry
Published: January 10, 2025
CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.
Journal: Acta pharmaceutica Sinica. B
Published: October 30, 2024
Preclinical and first-in-human of purinostat mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed/refractory multiple myeloma and lymphoma.
Journal: Signal transduction and targeted therapy
Published: October 02, 2024
Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1H-benzo[d]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the "Clamp" Strategy.
Journal: Journal of medicinal chemistry
Published: August 21, 2024
Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms.
Journal: Blood cancer journal
Published: June 26, 2024
Last Updated: 09/26/2026