Jianzhao Zhang

Key Laboratory Of Molecular Pharmacology And Drug Evaluation
Yantai, 264005, China

Last Updated: 09/26/2026

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Found 25 publications

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist.

Preclinical and Toxicology Studies of LPM7100328, a Novel Oral GnRH Antagonist.

Journal: Pharmacology research & perspectives

Published: February 22, 2026

TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront.

TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront.

Journal: Frontiers in pharmacology

Published: December 03, 2025

Discovery of a novel Nrf2 activator that modulates mitochondrial function in neurons by regulating DHRS3-Nrf2 interaction after ischemic stroke.

Discovery of a novel Nrf2 activator that modulates mitochondrial function in neurons by regulating DHRS3-Nrf2 interaction after ischemic stroke.

Journal: Theranostics

Published: November 18, 2025

Targeting RIPK1-mediated necroptosis, oxidative stress, and ferroptosis: A novel multitarget therapy for ischemic stroke.

Targeting RIPK1-mediated necroptosis, oxidative stress, and ferroptosis: A novel multitarget therapy for ischemic stroke.

Journal: European journal of medicinal chemistry

Published: May 01, 2025

Development of a Highly Potent Neurokinin‑3 Receptor Inhibitor: Design, Synthesis, and Evaluation.

Development of a Highly Potent Neurokinin‑3 Receptor Inhibitor: Design, Synthesis, and Evaluation.

Journal: ACS medicinal chemistry letters

Published: April 28, 2025

Rational Design of the First Dual Agonist at Trace Amine-Associated Receptor 1 and 5-HT2C Receptors Based on Binding Pocket Similarity for the Treatment of Schizophrenia and Alzheimer's Disease-Related Psychosis.

Rational Design of the First Dual Agonist at Trace Amine-Associated Receptor 1 and 5-HT2C Receptors Based on Binding Pocket Similarity for the Treatment of Schizophrenia and Alzheimer's Disease-Related Psychosis.

Journal: Journal of medicinal chemistry

Published: March 31, 2025

Synthesis and evaluation of novel 5-HT2A receptor inverse agonist with excellent in vivo antipsychotic efficacy and superior tissue distribution for treatment of Parkinson's disease psychosis.

Synthesis and evaluation of novel 5-HT2A receptor inverse agonist with excellent in vivo antipsychotic efficacy and superior tissue distribution for treatment of Parkinson's disease psychosis.

Journal: European journal of medicinal chemistry

Published: March 11, 2025

Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP-Deficient Glioma May Be Influenced by Surrounding Normal Cells.

Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP-Deficient Glioma May Be Influenced by Surrounding Normal Cells.

Journal: Cancer medicine

Published: August 12, 2024

Ferroptosis in Ischemic Stroke and Related Traditional Chinese Medicines.

Ferroptosis in Ischemic Stroke and Related Traditional Chinese Medicines.

Journal: Molecules (Basel, Switzerland)

Published: June 20, 2024

Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer.

Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer.

Journal: European journal of medicinal chemistry

Published: January 21, 2024

Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53.

Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53.

Journal: Molecules (Basel, Switzerland)

Published: January 03, 2024

Biological evaluation and in silico studies of novel compounds as potent TAAR1 agonists that could be used in schizophrenia treatment.

Biological evaluation and in silico studies of novel compounds as potent TAAR1 agonists that could be used in schizophrenia treatment.

Journal: Frontiers in pharmacology

Published: February 09, 2023

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Last Updated: 09/26/2026