Jim G. Middelburg
Leiden, ZH, Netherlands
Last Updated: 09/26/2026
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Found 21 publications
The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis.
Journal: Frontiers in immunology
Published: November 10, 2025
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes.
Journal: Nature immunology
Published: February 16, 2025
Improving CD3 bispecific antibody therapy in solid tumors using combination strategies.
Journal: Frontiers in oncology
Published: December 19, 2024
Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapy.
Journal: Journal for immunotherapy of cancer
Published: November 23, 2024
Site-directed multivalent conjugation of antibodies to ubiquitinated payloads.
Journal: Nature biomedical engineering
Published: March 26, 2024
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery.
Journal: Nature
Published: December 14, 2023
T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors.
Journal: Nature communications
Published: October 13, 2023
Longitudinal evaluation of the biodistribution and cellular internalization of the bispecific CD3xTRP1 antibody in syngeneic mouse tumor models.
Journal: Journal for immunotherapy of cancer
Published: October 04, 2023
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy.
Journal: Cancer cell
Published: September 29, 2023
The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent.
Journal: Cell reports
Published: June 13, 2023
Last Updated: 09/26/2026