Jiqing Guo

507 Campus Drive
Calgary, AB, Canada

Last Updated: 09/26/2026

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Found 19 publications

Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.

Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.

Journal: ACS pharmacology & translational science

Published: November 10, 2023

The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.

The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.

Journal: Biophysical journal

Published: March 22, 2022

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.

Journal: Journal of chemical information and modeling

Published: August 23, 2021

Refinement of a cryo-EM structure of hERG: Bridging structure and function.

Refinement of a cryo-EM structure of hERG: Bridging structure and function.

Journal: Biophysical journal

Published: September 11, 2020

Lipid regulation of hERG1 channel function.

Lipid regulation of hERG1 channel function.

Journal: Nature communications

Published: June 04, 2020

Selectivity filter modalities and rapid inactivation of the hERG1 channel.

Selectivity filter modalities and rapid inactivation of the hERG1 channel.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: January 26, 2020

Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade.

Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade.

Journal: Frontiers in pharmacology

Published: December 16, 2019

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Journal: Molecular pharmacology

Published: December 21, 2018

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.

Journal: Frontiers in physiology

Published: August 30, 2017

Reversible Dilated Cardiomyopathy Caused by a High Burden of Ventricular Arrhythmias in Andersen-Tawil Syndrome.

Reversible Dilated Cardiomyopathy Caused by a High Burden of Ventricular Arrhythmias in Andersen-Tawil Syndrome.

Journal: The Canadian journal of cardiology

Published: May 24, 2016

Role of the pH in state-dependent blockade of hERG currents.

Role of the pH in state-dependent blockade of hERG currents.

Journal: Scientific reports

Published: May 13, 2016

In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".

In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".

Journal: Journal of molecular and cellular cardiology

Published: July 23, 2015

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Last Updated: 09/26/2026