Jiri Sedmik

Brno, JM 62500, Czech Republic

Last Updated: 09/26/2026

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Found 18 publications

Taurine inhibits apolipoprotein E4 aggregation.

Taurine inhibits apolipoprotein E4 aggregation.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: February 23, 2026

SORL1 variant links endosomal amyloid precursor protein mis-sorting to axonal transport defects and neuronal dysfunction.

SORL1 variant links endosomal amyloid precursor protein mis-sorting to axonal transport defects and neuronal dysfunction.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: January 15, 2026

ADAR1 and ADAR2 associate with the RNA exosome and modulate RNA stability.

ADAR1 and ADAR2 associate with the RNA exosome and modulate RNA stability.

Journal: Nucleic acids research

Published: January 05, 2026

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction.

Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction.

Journal: Cellular and molecular neurobiology

Published: December 16, 2025

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants.

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: September 12, 2025

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models.

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models.

Journal: bioRxiv : the preprint server for biology

Published: July 15, 2025

Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer's Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control.

Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer's Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control.

Journal: Stem cell research

Published: October 16, 2023

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.

Journal: Molecular neurodegeneration

Published: November 06, 2022

ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations.

ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations.

Journal: RNA (New York, N.Y.)

Published: July 21, 2022

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration.

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration.

Journal: Molecular oncology

Published: May 05, 2022

Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.

Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.

Journal: Cell reports

Published: March 28, 2022

Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.

Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.

Journal: Stem cell reviews and reports

Published: August 28, 2021

Showing 1-12 of 18

Last Updated: 09/26/2026