Jo Waaler

Oslo, 0372, Norway

Last Updated: 09/26/2026

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Found 25 publications

Discovery of tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain.

Discovery of tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain.

Journal: Structure (London, England : 1993)

Published: April 17, 2025

Deconstruction of Dual-Site Tankyrase Inhibitors Provides Insights into Binding Energetics and Suggests Critical Hotspots for Ligand Optimization.

Deconstruction of Dual-Site Tankyrase Inhibitors Provides Insights into Binding Energetics and Suggests Critical Hotspots for Ligand Optimization.

Journal: Journal of medicinal chemistry

Published: March 26, 2025

Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.

Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.

Journal: European journal of medicinal chemistry

Published: November 28, 2024

A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors.

A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors.

Journal: Biomedicines

Published: September 05, 2023

The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models.

The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models.

Journal: Cancer research communications

Published: January 18, 2022

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.

Journal: Journal of medicinal chemistry

Published: December 08, 2021

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines.

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines.

Journal: iScience

Published: February 09, 2021

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.

Journal: Journal of medicinal chemistry

Published: June 09, 2020

A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation.

A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation.

Journal: Cancers

Published: May 31, 2020

Correction: Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation.

Correction: Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation.

Journal: RSC advances

Published: January 09, 2020

Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation.

Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation.

Journal: RSC advances

Published: September 12, 2019

Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice.

Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice.

Journal: International journal of obesity (2005)

Published: September 06, 2019

Showing 1-12 of 25

Last Updated: 09/26/2026