Joanna M. Watt

Oxford, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 11 publications

Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2.

Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2.

Journal: Nature communications

Published: July 22, 2025

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5'-monophosphate, Analogues and Early Structure-Activity Relationship.

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5'-monophosphate, Analogues and Early Structure-Activity Relationship.

Journal: Molecules (Basel, Switzerland)

Published: November 08, 2021

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR).

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR).

Journal: RSC advances

Published: January 15, 2020

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR.

Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR.

Journal: Scientific reports

Published: September 04, 2018

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers.

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers.

Journal: Scientific reports

Published: May 08, 2018

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease.

Journal: Scientific reports

Published: March 27, 2018

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

Journal: Antioxidants & redox signaling

Published: August 11, 2017

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: July 19, 2017

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid "L-cyclic inosine 5'-diphosphate ribose".

Journal: Scientific reports

Published: May 26, 2017

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

Journal: The Biochemical journal

Published: January 27, 2017

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

Journal: Nature chemical biology

Published: January 11, 2017

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Last Updated: 09/26/2026