Jochen Kuhnl

Hamburg, HH 22529, Germany

Last Updated: 09/26/2026

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Found 29 publications

Increasing Accessibility of Bayesian Network-Based Defined Approaches for Skin Sensitisation Potency Assessment.

Increasing Accessibility of Bayesian Network-Based Defined Approaches for Skin Sensitisation Potency Assessment.

Journal: Toxics

Published: July 26, 2024

Characterization of the in vitro penetration and first-pass metabolism of genistein and daidzein using human and pig skin explants and Phenion full-thickness skin models.

Characterization of the in vitro penetration and first-pass metabolism of genistein and daidzein using human and pig skin explants and Phenion full-thickness skin models.

Journal: Journal of applied toxicology : JAT

Published: April 22, 2024

Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment.

Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment.

Journal: Frontiers in pharmacology

Published: April 22, 2024

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion.

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion.

Journal: Frontiers in pharmacology

Published: April 22, 2024

Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full-thickness skin model.

Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full-thickness skin model.

Journal: Journal of applied toxicology : JAT

Published: April 22, 2024

A novel three-dimensional Nrf2 reporter epidermis model for skin sensitization assessment.

A novel three-dimensional Nrf2 reporter epidermis model for skin sensitization assessment.

Journal: Toxicology

Published: December 20, 2023

Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure.

Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure.

Journal: Frontiers in pharmacology

Published: November 28, 2023

Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein.

Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein.

Journal: Journal of applied toxicology : JAT

Published: July 19, 2023

Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene.

Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene.

Journal: Journal of applied toxicology : JAT

Published: July 18, 2023

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions.

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions.

Journal: Frontiers in pharmacology

Published: October 21, 2022

Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data.

Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data.

Journal: Regulatory toxicology and pharmacology : RTP

Published: April 13, 2022

Predicting the Skin Sensitization Potential of Small Molecules with Machine Learning Models Trained on Biologically Meaningful Descriptors.

Predicting the Skin Sensitization Potential of Small Molecules with Machine Learning Models Trained on Biologically Meaningful Descriptors.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: July 14, 2021

Showing 1-12 of 29

Last Updated: 09/26/2026