Johan Lundkvist

Former AstraZeneca R&D
Soedertaelje, AB, Sweden

Last Updated: 09/26/2026

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Found 19 publications

Response to the Letter to the Editor on "γ-Secretase modulation and plaque regression in Alzheimer's disease".

Response to the Letter to the Editor on "γ-Secretase modulation and plaque regression in Alzheimer's disease".

Journal: The Journal of pharmacology and experimental therapeutics

Published: August 12, 2025

Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies.

Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies.

Journal: Pharmacological research

Published: July 15, 2025

Gene therapy device-based delivery of progranulin, prosaposin, and GDNF as a combined precision and neurorestorative therapy in the rat 6-OHDA model of parkinsonism.

Gene therapy device-based delivery of progranulin, prosaposin, and GDNF as a combined precision and neurorestorative therapy in the rat 6-OHDA model of parkinsonism.

Journal: Experimental neurology

Published: February 24, 2025

γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice.

γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice.

Journal: The Journal of pharmacology and experimental therapeutics

Published: September 27, 2024

Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease.

Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease.

Journal: Frontiers in molecular neuroscience

Published: August 18, 2023

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model.

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model.

Journal: EMBO molecular medicine

Published: July 08, 2022

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

Journal: Nature communications

Published: May 08, 2022

γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.

γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.

Journal: Journal of cellular and molecular medicine

Published: September 17, 2020

Endogenous APP accumulates in synapses after BACE1 inhibition.

Endogenous APP accumulates in synapses after BACE1 inhibition.

Journal: Neuroscience research

Published: June 08, 2015

Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.

Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.

Journal: Journal of neurochemistry

Published: July 11, 2014

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

Journal: FEBS open bio

Published: April 11, 2014

The battle of Alzheimer's Disease - the beginning of the future Unleashing the potential of academic discoveries.

The battle of Alzheimer's Disease - the beginning of the future Unleashing the potential of academic discoveries.

Journal: Frontiers in pharmacology

Published: March 04, 2014

Showing 1-12 of 19

Last Updated: 09/26/2026