Johan Nicolai
Beerse, VLG, Belgium
Last Updated: 09/26/2026
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Found 22 publications
Deconvoluting the in vitro to in vivo drug clearance gap: Questioning the predictive performance of traditional hepatic clearance models.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Published: November 27, 2025
Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.
Journal: Journal of medicinal chemistry
Published: August 26, 2025
Toward improved clearance predictions and distribution profiles employing the isolated perfused rat liver model: Experimental optimization.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: November 25, 2024
Drug clearance by aldehyde oxidase: can we avoid clinical failure?
Journal: Xenobiotica; the fate of foreign compounds in biological systems
Published: September 28, 2022
The role of the efflux transporter, P-glycoprotein, at the blood-brain barrier in drug discovery.
Journal: Biopharmaceutics & drug disposition
Published: August 11, 2022
A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age-dependent differences in absorption.
Journal: Clinical and translational science
Published: June 01, 2022
Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: June 01, 2021
Meropenem Pharmacokinetics and Target Attainment in Critically Ill Patients Are Not Affected by Extracorporeal Membrane Oxygenation: A Matched Cohort Analysis.
Journal: Microorganisms
Published: May 18, 2021
Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium.
Journal: Clinical and translational science
Published: May 19, 2020
Population pharmacokinetics of propofol in neonates and infants: Gestational and postnatal age to determine clearance maturation.
Journal: British journal of clinical pharmacology
Published: May 10, 2020
(-)-N-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-N-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: April 20, 2020
Use of a physiologically based pharmacokinetic-pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial.
Journal: British journal of clinical pharmacology
Published: April 17, 2020
Last Updated: 09/26/2026