Johannes L. Bos

Utrecht, UT, Netherlands

Last Updated: 09/26/2026

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Found 28 publications

Author Correction: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Author Correction: Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Journal: Nature cell biology

Published: July 31, 2026

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.

Journal: Cell reports

Published: March 02, 2021

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Journal: Nature cell biology

Published: February 21, 2020

CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition.

CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition.

Journal: Oncotarget

Published: December 12, 2018

A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization.

A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization.

Journal: PloS one

Published: July 31, 2018

The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size.

The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size.

Journal: Molecular and cellular biology

Published: February 27, 2018

Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions.

Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions.

Journal: Small GTPases

Published: February 02, 2018

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.

Journal: Nature medicine

Published: November 28, 2017

From Ras to Rap and Back, a Journey of 35 Years.

From Ras to Rap and Back, a Journey of 35 Years.

Journal: Cold Spring Harbor perspectives in medicine

Published: August 06, 2017

Ras Association-Domain Dimers Bring Proteins Together.

Ras Association-Domain Dimers Bring Proteins Together.

Journal: Structure (London, England : 1993)

Published: December 08, 2016

A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization.

A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization.

Journal: Molecular and cellular biology

Published: October 04, 2016

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.

Journal: eLife

Published: June 05, 2016

Showing 1-12 of 28

Last Updated: 09/26/2026