John E. Linley

Gower Street
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 25 publications

Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease.

Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease.

Journal: Pain reports

Published: January 09, 2026

The rise and fall of SARM1 base-exchange inhibitors.

The rise and fall of SARM1 base-exchange inhibitors.

Journal: Communications chemistry

Published: December 19, 2025

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.

Journal: bioRxiv : the preprint server for biology

Published: October 01, 2025

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response.

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response.

Journal: Nature communications

Published: February 13, 2025

SLC45A4 is a pain gene encoding a neuronal polyamine transporter.

SLC45A4 is a pain gene encoding a neuronal polyamine transporter.

Journal: Nature

Published: September 05, 2024

Pain in fibrous dysplasia: identifying nociceptive mechanisms in a preclinical model.

Pain in fibrous dysplasia: identifying nociceptive mechanisms in a preclinical model.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Published: May 11, 2024

Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine.

Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine.

Journal: Brain : a journal of neurology

Published: April 15, 2024

Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia.

Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia.

Journal: eNeuro

Published: September 20, 2022

Calcium imaging for analgesic drug discovery.

Calcium imaging for analgesic drug discovery.

Journal: Neurobiology of pain (Cambridge, Mass.)

Published: November 10, 2021

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.

Journal: Pain

Published: May 03, 2019

Screening Strategies for the Discovery of Ion Channel Monoclonal Antibodies.

Screening Strategies for the Discovery of Ion Channel Monoclonal Antibodies.

Journal: Current protocols in pharmacology

Published: September 01, 2018

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.

Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice.

Journal: The EMBO journal

Published: April 05, 2017

Showing 1-12 of 25

Last Updated: 09/26/2026