John F. Dawson
Guelph, ON, Canada
Last Updated: 09/26/2026
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Found 22 publications
Actin's functional "switch": Constraining C-terminal conformational flexibility disrupts functionally important communication networks.
Journal: The Journal of biological chemistry
Published: October 31, 2025
Early pre-symptomatic and sex-specific cardiac remodeling precedes heart failure in zebrafish with human actin mutation.
Journal: Disease models & mechanisms
Published: September 30, 2025
Pseudo-acetylation of ACTC1 K326 and K328 promotes dysinhibition of reconstituted human cardiac thin filaments.
Journal: Journal of molecular and cellular cardiology
Published: August 28, 2025
The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction.
Journal: iScience
Published: July 15, 2024
Duality in disease: How two amino acid substitutions at actin residue 312 result in opposing forms of cardiomyopathy.
Journal: The Journal of biological chemistry
Published: June 29, 2024
Actin's C-terminus coordinates actin structural changes and functions.
Journal: Cytoskeleton (Hoboken, N.J.)
Published: October 31, 2022
A gradient of force generation at rest differentiates cardiomyopathy outcomes with variants of actin located at the same residue.
Journal: Journal of molecular and cellular cardiology plus
Published: June 13, 2022
Increasing the calcium sensitivity of muscle using trifluoperazine-induced manipulations in silico, in vitro and in vivo systems.
Journal: Archives of biochemistry and biophysics
Published: May 04, 2022
Homology-Directed Repair in Zebrafish: Witchcraft and Wizardry?
Journal: Frontiers in molecular biosciences
Published: August 16, 2020
The Dark Side of Actin: Cardiac actin variants highlight the role of allostery in disease development.
Journal: Archives of biochemistry and biophysics
Published: June 30, 2020
Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases.
Journal: International journal of molecular sciences
Published: December 17, 2019
M-class hypertrophic cardiomyopathy cardiac actin mutations increase calcium sensitivity of regulated thin filaments.
Journal: Biochemical and biophysical research communications
Published: August 22, 2019
Last Updated: 09/26/2026