John P. Wiebe

London, ON N6A5B7, Canada

Last Updated: 09/26/2026

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Found 10 publications

Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation.

Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation.

Journal: The Journal of steroid biochemistry and molecular biology

Published: August 18, 2015

Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride.

Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride.

Journal: The Journal of steroid biochemistry and molecular biology

Published: September 15, 2014

Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors.

Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors.

Journal: Breast cancer research : BCR

Published: December 03, 2012

Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines.

Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines.

Journal: The Journal of steroid biochemistry and molecular biology

Published: September 03, 2009

Progesterone metabolites in breast cancer.

Progesterone metabolites in breast cancer.

Journal: Endocrine-related cancer

Published: September 07, 2006

Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment.

Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment.

Journal: The Journal of steroid biochemistry and molecular biology

Published: February 20, 2006

Role of progesterone metabolites in mammary cancer.

Role of progesterone metabolites in mammary cancer.

Journal: The Journal of dairy research

Published: September 27, 2005

The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics.

The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics.

Journal: The Journal of steroid biochemistry and molecular biology

Published: April 30, 2005

Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells.

Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells.

Journal: BMC cancer

Published: February 14, 2003

The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells.

The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells.

Journal: Endocrine

Published: February 02, 2002

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Last Updated: 09/26/2026