Jon K. Obst

Vancouver, BC, Canada

Last Updated: 09/26/2026

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Found 8 publications

Drugging the intrinsically disordered transactivation domain of androgen receptor.

Drugging the intrinsically disordered transactivation domain of androgen receptor.

Journal: Signal transduction and targeted therapy
Published: October 07, 2025

Inhibitors of the transactivation domain of androgen receptor as a therapy for prostate cancer.

Inhibitors of the transactivation domain of androgen receptor as a therapy for prostate cancer.

Journal: Steroids
Published: May 10, 2024

Rational optimization of a transcription factor activation domain inhibitor.

Rational optimization of a transcription factor activation domain inhibitor.

Journal: Nature structural & molecular biology
Published: November 21, 2022

Differential Gene Expression Profiles between N-Terminal Domain and Ligand-Binding Domain Inhibitors of Androgen Receptor Reveal Ralaniten Induction of Metallothionein by a Mechanism Dependent on MTF1.

Differential Gene Expression Profiles between N-Terminal Domain and Ligand-Binding Domain Inhibitors of Androgen Receptor Reveal Ralaniten Induction of Metallothionein by a Mechanism Dependent on MTF1.

Journal: Cancers
Published: December 15, 2021

Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants.

Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants.

Journal: Cancers
Published: June 17, 2020

Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies.

Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies.

Journal: ACS pharmacology & translational science
Published: August 20, 2019

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation.

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation.

Journal: Translational cancer research
Published: September 01, 2016

Conditional protein splicing of α-sarcin in live cells.

Conditional protein splicing of α-sarcin in live cells.

Journal: Molecular bioSystems
Published: February 01, 2014
Showing 1-8 of 8

Last Updated: 09/26/2026