Jonas Mechtersheimer

London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 10 publications

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.

Journal: bioRxiv : the preprint server for biology

Published: October 01, 2025

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.

Journal: Nature communications

Published: April 14, 2023

ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells.

ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells.

Journal: Scientific reports

Published: September 25, 2020

FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.

FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.

Journal: The Journal of cell biology

Published: August 08, 2020

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Journal: Nature communications

Published: June 14, 2020

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.

Journal: Nucleic acids research

Published: November 09, 2019

Generation of Gene Knockout and Gene Replacement with Complete Removal of Full-length Endogenous Transcript Using CRISPR-Trap.

Generation of Gene Knockout and Gene Replacement with Complete Removal of Full-length Endogenous Transcript Using CRISPR-Trap.

Journal: Bio-protocol

Published: June 08, 2018

The emerging role of minor intron splicing in neurological disorders.

The emerging role of minor intron splicing in neurological disorders.

Journal: Cell stress

Published: February 22, 2018

Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice.

Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice.

Journal: Neurobiology of stress

Published: November 28, 2017

CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells.

CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells.

Journal: Molecular biology of the cell

Published: May 11, 2017

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Last Updated: 09/26/2026