Jonathan E. Knikman

Utrecht, UT, Netherlands

Last Updated: 09/26/2026

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Found 19 publications

Personalised approach to hypertension treatment: protocol for the HYPERMARKER randomised controlled trial.

Personalised approach to hypertension treatment: protocol for the HYPERMARKER randomised controlled trial.

Journal: BMJ open

Published: July 16, 2026

Pharmacokinetics of 5-Fluorouracil in Patients Treated With Capecitabine Carrying the c.1236G>A DPYD Variant Allele.

Pharmacokinetics of 5-Fluorouracil in Patients Treated With Capecitabine Carrying the c.1236G>A DPYD Variant Allele.

Journal: JCO precision oncology

Published: June 08, 2026

The SHERPA trial: A phase I study combining SHP2 inhibitor RMC-4630 and ERK inhibitor LY3214996 in patients with KRAS-mutant pancreatic, non-small cell lung and colorectal cancer.

The SHERPA trial: A phase I study combining SHP2 inhibitor RMC-4630 and ERK inhibitor LY3214996 in patients with KRAS-mutant pancreatic, non-small cell lung and colorectal cancer.

Journal: European journal of cancer (Oxford, England : 1990)

Published: November 20, 2025

Predictors of poor treatment tolerability in older patients receiving fluoropyrimidine-based chemotherapy: A prospective cohort study.

Predictors of poor treatment tolerability in older patients receiving fluoropyrimidine-based chemotherapy: A prospective cohort study.

Journal: Journal of geriatric oncology

Published: October 21, 2025

Dietary modification of blood pressure-lowering effects of antihypertensive drugs - a scoping review.

Dietary modification of blood pressure-lowering effects of antihypertensive drugs - a scoping review.

Journal: Journal of hypertension

Published: September 15, 2025

Dietary modification of blood pressure-lowering effects of antihypertensive drugs - a scoping review.

Dietary modification of blood pressure-lowering effects of antihypertensive drugs - a scoping review.

Journal: Journal of hypertension

Published: September 15, 2025

Response to Letter Re: Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels.

Response to Letter Re: Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels.

Journal: European journal of cancer (Oxford, England : 1990)

Published: September 04, 2025

Pharmacometabolomics of treatment response to antihypertensive drugs: a systematic review.

Pharmacometabolomics of treatment response to antihypertensive drugs: a systematic review.

Journal: Journal of hypertension

Published: August 25, 2025

Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study.

Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study.

Journal: European journal of cancer (Oxford, England : 1990)

Published: February 04, 2025

Severe fluoropyrimidine toxicity in older adults with cancer with DPYD wild type.

Severe fluoropyrimidine toxicity in older adults with cancer with DPYD wild type.

Journal: Fundamental & clinical pharmacology

Published: June 28, 2024

Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD.

Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD.

Journal: Genome medicine

Published: March 29, 2024

Survival of Patients With Cancer With DPYD Variant Alleles and Dose-Individualized Fluoropyrimidine Therapy-A Matched-Pair Analysis.

Survival of Patients With Cancer With DPYD Variant Alleles and Dose-Individualized Fluoropyrimidine Therapy-A Matched-Pair Analysis.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Published: August 28, 2023

Showing 1-12 of 19

Last Updated: 09/26/2026