Jonathan M. Large

Mill Hill
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 21 publications

Design and Synthesis of Pyrazoline Inhibitors of SARS-CoV‑2 NSP14.

Design and Synthesis of Pyrazoline Inhibitors of SARS-CoV‑2 NSP14.

Journal: ACS medicinal chemistry letters

Published: March 20, 2025

XAT-Catalysis for Intramolecular Biaryl Synthesis.

XAT-Catalysis for Intramolecular Biaryl Synthesis.

Journal: Angewandte Chemie (International ed. in English)

Published: April 26, 2024

Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?

Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?

Journal: Frontiers in molecular neuroscience

Published: January 14, 2024

Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade.

Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade.

Journal: Organic letters

Published: September 05, 2023

Aryne-Enabled C-N Arylation of Anilines.

Aryne-Enabled C-N Arylation of Anilines.

Journal: Angewandte Chemie (International ed. in English)

Published: July 25, 2023

Diarylamine Synthesis via Desulfinylative Smiles Rearrangement.

Diarylamine Synthesis via Desulfinylative Smiles Rearrangement.

Journal: Organic letters

Published: January 31, 2022

Aprepitant is a novel, selective activator of the K2P channel TRAAK.

Aprepitant is a novel, selective activator of the K2P channel TRAAK.

Journal: Biochemical and biophysical research communications

Published: December 09, 2021

A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels.

A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels.

Journal: SLAS discovery : advancing life sciences R & D

Published: December 30, 2020

Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs.

Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs.

Journal: Frontiers in microbiology

Published: September 04, 2020

Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.

Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.

Journal: Biochemical and biophysical research communications

Published: September 06, 2019

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Journal: Bioorganic & medicinal chemistry letters

Published: July 01, 2019

Developing an Antibody-Drug Conjugate Approach to Selective Inhibition of an Extracellular Protein.

Developing an Antibody-Drug Conjugate Approach to Selective Inhibition of an Extracellular Protein.

Journal: Chembiochem : a European journal of chemical biology

Published: October 15, 2018

Showing 1-12 of 21

Last Updated: 09/26/2026