Jorg Tatzelt

Bochum, NW 44801, Germany

Last Updated: 09/26/2026

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Found 51 publications

Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs.

Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs.

Journal: BBA advances

Published: November 12, 2025

Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.

Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.

Journal: Acta neuropathologica communications

Published: September 10, 2025

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration.

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: June 02, 2025

Soluble N-Terminal Domain of the Prion Protein Interferes with Fibrillization of α-Synuclein to Form Off-Pathway Assemblies that Lack Cellular Seeding Activity.

Soluble N-Terminal Domain of the Prion Protein Interferes with Fibrillization of α-Synuclein to Form Off-Pathway Assemblies that Lack Cellular Seeding Activity.

Journal: ACS chemical neuroscience

Published: May 07, 2025

Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases.

Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: December 31, 2024

Regulated Proteolysis Induces Aberrant Phase Transition of Biomolecular Condensates into Aggregates: A Protective Role for the Chaperone Clusterin.

Regulated Proteolysis Induces Aberrant Phase Transition of Biomolecular Condensates into Aggregates: A Protective Role for the Chaperone Clusterin.

Journal: Journal of molecular biology

Published: June 07, 2024

Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X.

Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X.

Journal: Nature communications

Published: May 06, 2024

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.

Journal: Acta neuropathologica

Published: April 24, 2024

Morphological Transformations of SARS-CoV-2 Nucleocapsid Protein Biocondensates Mediated by Antimicrobial Peptides.

Morphological Transformations of SARS-CoV-2 Nucleocapsid Protein Biocondensates Mediated by Antimicrobial Peptides.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: January 05, 2024

Liquid-liquid phase separation of the prion protein is regulated by the octarepeat domain independently of histidines and copper.

Liquid-liquid phase separation of the prion protein is regulated by the octarepeat domain independently of histidines and copper.

Journal: The Journal of biological chemistry

Published: December 27, 2023

VCP/p97 mediates nuclear targeting of non-ER-imported prion protein to maintain proteostasis.

VCP/p97 mediates nuclear targeting of non-ER-imported prion protein to maintain proteostasis.

Journal: Life science alliance

Published: October 25, 2023

Hydration makes a difference! How to tune protein complexes between liquid-liquid and liquid-solid phase separation.

Hydration makes a difference! How to tune protein complexes between liquid-liquid and liquid-solid phase separation.

Journal: Physical chemistry chemical physics : PCCP

Published: October 16, 2023

Showing 1-12 of 51

Last Updated: 09/26/2026