Jorge M. Charco

Bizkaia Technology Park
Derio, PV, Spain

Last Updated: 09/26/2026

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Found 25 publications

Rapid generation of prion disease models using AAV-delivered PrP variants in knockout mice.

Rapid generation of prion disease models using AAV-delivered PrP variants in knockout mice.

Journal: Brain pathology (Zurich, Switzerland)

Published: December 01, 2025

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains.

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains.

Journal: Brain pathology (Zurich, Switzerland)

Published: September 09, 2025

Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness.

Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness.

Journal: Acta neuropathologica communications

Published: August 26, 2025

Spontaneous generation of diverse recombinant prion strains: sulfated glycan cofactors facilitate strain emergence but do not determine specific strain properties.

Spontaneous generation of diverse recombinant prion strains: sulfated glycan cofactors facilitate strain emergence but do not determine specific strain properties.

Journal: Acta neuropathologica communications

Published: June 12, 2025

Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity.

Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity.

Journal: Neurobiology of disease

Published: April 10, 2025

A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene.

A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene.

Journal: PLoS pathogens

Published: February 14, 2025

Conservation of strain properties of bank vole-adapted chronic wasting disease in the absence of glycosylation and membrane anchoring.

Conservation of strain properties of bank vole-adapted chronic wasting disease in the absence of glycosylation and membrane anchoring.

Journal: Neurobiology of disease

Published: January 29, 2025

Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions.

Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions.

Journal: PLoS pathogens

Published: October 04, 2024

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions.

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions.

Journal: Nature communications

Published: October 13, 2023

Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation.

Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation.

Journal: Acta neuropathologica communications

Published: June 29, 2023

Analysis of a large case series of fatal familial insomnia to determine tests with the highest diagnostic value.

Analysis of a large case series of fatal familial insomnia to determine tests with the highest diagnostic value.

Journal: Journal of neuropathology and experimental neurology

Published: December 02, 2022

Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model.

Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model.

Journal: Acta neuropathologica communications

Published: September 16, 2022

Showing 1-12 of 25

Last Updated: 09/26/2026